Exploiting uniqueness: seed-chain-extend alignment on elastic founder graphs
We implement a complete seed-chain-extend alignment workflow based on indexable elastic founder graphs (iEFGs). We show how to construct iEFGs from the variations to a linear reference, find high-quality seeds, and extend them using GraphAligner, at the scale of a telomere-to-telomere assembled human chromosome.
Nov 26, 2024
